Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol LevelArticle Published on 2023-04-252023-06-12 Journal: mBio [Category] E형 간염, Fulltext, [키워드] estradiol fetal loss Genotype 3 HEV Hepatitis E virus (HEV) Inflammatory cytokines Pregnancy rabbit HEV. [DOI] 10.1128/mbio.00418-23 PMC 바로가기
Estrogen hormone is an essential sex factor inhibiting inflammation and immune response in COVID-19에스트로겐 호르몬은 COVID-19에서 염증과 면역 반응을 억제하는 필수 성 인자입니다Article Published on 2022-06-082022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법, 치료제, [키워드] age approved caused COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 treatment death drug effective ESR1 ESR2 estradiol estriol Estrogen Estrogens estrone evaluated Factor Fatality rate female Genetic genetic factors Host host cells immune response increase indicated infected with SARS-CoV-2 Inflammation inhibit SARS-CoV-2 inhibiting lack male mechanism medication medications men Mortality mortality rate network analysis proportion PROTECT receptors reduce SARS-COV-2 infection Sex Signaling signaling pathway signaling pathways significantly synergistic target targets Treatment unique Vaccine with COVID-19 women [DOI] 10.1038/s41598-022-13585-4 PMC 바로가기 [Article Type] Article
Female-biased effects of aging on a chimeric hemagglutinin stalk-based universal influenza virus vaccine in miceArticle Published on 2022-03-082023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] aging estradiol flu vaccine influenza A virus Sex difference Testosterone. [DOI] 10.1016/j.vaccine.2020.11.057 PMC 바로가기
Association Between Sex Hormone Levels and Clinical Outcomes in Patients With COVID-19 Admitted to Hospital: An Observational, Retrospective, Cohort StudyObservational Study Published on 2022-01-272022-10-04 Journal: Frontiers in Immunology [Category] 임상, [키워드] age ARDS association both sexes clinical cohort study confounders COVID-19 COVID-19 patients death estradiol hormone Hospitalized in-hospital mortality Italy Level male males median age Older outcome Patient Probability progesterone Protective Regression model reported retrospective severe COVID-19 severity Sex sex hormone Sex hormones stratified by sex STROBE survivor Testosterone understanding with COVID-19 [DOI] 10.3389/fimmu.2022.834851 PMC 바로가기 [Article Type] Observational Study
DrugWAS: Drug-wide Association Studies for COVID-19 Drug RepurposingDrugWAS: COVID-19 약물 용도 변경에 대한 약물 전반의 협회 연구Article Published on 2021-12-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] MERS, 신약개발, [키워드] 95% CI 95% confidence interval Admission analysis Analysis applied association azelastine center clinical trials cohort study coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 severity death Dextromethorphan diphtheria toxoid drug drugs Efficacy EHR EHR data Electronic health record estradiol ethinyl estradiol exposure to fatty acids Flaxseed fluticasone Health health record ibuprofen identify IMPROVE intensive care intensive care unit list lower risk mechanical ventilation multivariable logistic regression Odds ratio omega-3 Omega-3 fatty acids outcomes overlap pandemic patients with COVID-19 performed pertussis vaccine pneumococcal polysaccharide vaccine Potential treatment Primary outcome Propensity score pseudoephedrine randomized clinical trial repurposing retrospective cohort risk of death secondary Secondary analyses Secondary outcomes significantly tetanus toxoid ubidecarenone university Vaccine Vaccines was selected Weighting [DOI] 10.1002/cpt.2376 PMC 바로가기 [Article Type] Article
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers입원 성별 바이오 마커에 의해 SARS-COV-2에 의해 감염된 환자의 호흡기 부전 예측Research Published on 2021-11-222022-08-31 Journal: Biology of Sex Differences [Category] MERS, SARS, 바이오마커, [키워드] 17β-estradiol ACE2 acute respiratory distress acute respiratory distress syndrome Admission affecting analysed Angiotensin1-7 ARDS association Biomarker Biomarkers choice circulating COVID-19 COVID-19 patient COVID-19 severity Definition Deterioration discharged estradiol Estrogen female female patient Female patients females Gender hospital Hospitalization identify lymphocyte Lymphocytes male males neutrophil neutrophil count Occurrence outcome Patient plasma plasma biomarker Plasma level Plasma levels predict predicted Predictive progression respiratory respiratory distress Respiratory failure Result SARS-CoV-2 severe respiratory failure severity Sex Sex difference sex hormone Sex hormones specific biomarker syndrome Testosterone were measured worsening [DOI] 10.1186/s13293-021-00407-x PMC 바로가기 [Article Type] Research
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study높은 에스트라디올과 낮은 테스토스테론 수치는 남성의 심각한 질병과 관련이 있지만 여성의 COVID-19 환자와는 관련이 없습니다: 후향적 코호트 연구Original Article Published on 2021-09-142022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 치료기술, [키워드] Admission analysed chemokine chemokines cohorts Comorbidity COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients Critical Critical illness Critically ill cytokine Cytokines death disease severity ECMO elevated estradiol estradiol level female hallmark healthy individual healthy individuals Heart diseases ICU IFN-γ intensive care intensive care unit Linear regression analysis male metabolism non-COVID-19 patient Non-COVID-19 patients prevalent receive reduced regression analysis retrospective cohort study risk factor SARS-CoV-2 Sex sex differences sex hormone Sex hormones significantly statistically significant difference Testosterone Treatment [DOI] 10.1080/22221751.2021.1969869 PMC 바로가기 [Article Type] Original Article
Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver FailureOriginal Research Published on 2021-09-082023-08-30 Journal: Frontiers in Medicine [Category] E형 간염, [키워드] ACLF (acute-on-chronic liver failure) estradiol hepatitis B Mortality Prognosis testosterone (androgen) [DOI] 10.3389/fmed.2021.729030 PMC 바로가기 [Article Type] Original Research
Sex steroid hormones are associated with mortality in COVID-19 patients Level of sex hormones in severe COVID-19Observational Study Published on 2021-08-272022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] affected age albumin androgen association binding Biobank center coronavirus disease COVID-19 COVID-19 patient Deceased died disease severity estradiol estradiol level hormone hospital Infection interquartile range investigated Level median men men and women Mortality mortality rate Multiple outcome Patient patients with COVID-19 plasma sample residual selected severe COVID-19 Sex sex hormone sex steroid SHBG significantly lower surviving patients Testosterone therapy university were used women [DOI] 10.1097/MD.0000000000027072 PMC 바로가기 [Article Type] Observational Study
Sex steroids and COVID-19 mortality in womenCorrespondence Published on 2021-08-012022-10-05 Journal: Trends in endocrinology and metabolism: TEM [Category] SARS, 유전자 메커니즘, [키워드] coronavirus disease country COVID-19 COVID-19 mortality death died estradiol Estrogen Hormones Immunity men men and women Mortality progesterone PROTECT SARS-CoV-2 Sex Sex hormones sex steroid with COVID-19 women [DOI] 10.1016/j.tem.2021.04.006 [Article Type] Correspondence